Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
Read More
8
MNA+ enhances nitric oxide in vessels
Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.
We explored how N(1)-methylnicotinamide (MNA+) can improve blood vessel relaxation, particularly in those with high cholesterol. The study involved both healthy and hypercholesterolemic participants taking MNA+ and demonstrated significant improvements in flow-mediated dilation, which is linked to enhanced nitric oxide (NO) production.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
Read More
9
Niacin lowers cholesterol in diabetics
Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults.
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Read More
Most Useful Reviews
10
Significant cholesterol reduction
3 people found this helpful
I’m amazed at the results from taking omega-3 for my high cholesterol. My cholesterol levels decreased from 7.9 to 6 after just 1.5 months, as advised by my cardiologist, who suggested omega instead of statins. I’m really pleased with the outcome and will continue using it. It's recommended for everyone over 32, and it has certainly worked wonders for me.
Read More
7.5
Enhanced focus achieved
55 people found this helpful
The quality and concentration of Solgar's ingredients are exceptional. The B-complex has dramatically increased my focus and improved the health of my hair, skin, and nervous system. Vitamins B1, B2, B3, B6, B9, and B12 help in various ways, including hormone production and enhancing energy. Overall, I believe this B-complex contributes significantly to improved brain function and nervous system health, making it a valuable addition to my routine to address high cholesterol and overall well-being.
Read More
7.5
B vitamin potency
1 people found this helpful
I highly recommend Solgar's entire line due to its excellent quality, particularly the high mcg amounts in the B-complex. It’s especially beneficial for those lacking Vitamin B1, B6, and B12. These vitamins contribute significantly to my health and well-being, especially in regard to managing high cholesterol levels, making them crucial for anyone with deficiencies.
We explored the effectiveness of a dietary supplement combining red yeast rice and other natural compounds for lowering cholesterol in children with high cholesterol.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
Read More
9
Niacin lowers cholesterol in diabetics
Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults.
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Read More
9
Monacolin K significantly lowers LDL-C
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention.
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Read More
9
Effective cholesterol reduction noted
Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk.
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
Read More
9
Niacin reduces cholesterol and oxidative stress
Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
I’m amazed at the results from taking omega-3 for my high cholesterol. My cholesterol levels decreased from 7.9 to 6 after just 1.5 months, as advised by my cardiologist, who suggested omega instead of statins. I’m really pleased with the outcome and will continue using it. It's recommended for everyone over 32, and it has certainly worked wonders for me.
Read More
7.5
Enhanced focus achieved
55 people found this helpful
The quality and concentration of Solgar's ingredients are exceptional. The B-complex has dramatically increased my focus and improved the health of my hair, skin, and nervous system. Vitamins B1, B2, B3, B6, B9, and B12 help in various ways, including hormone production and enhancing energy. Overall, I believe this B-complex contributes significantly to improved brain function and nervous system health, making it a valuable addition to my routine to address high cholesterol and overall well-being.
Read More
7.5
B vitamin potency
1 people found this helpful
I highly recommend Solgar's entire line due to its excellent quality, particularly the high mcg amounts in the B-complex. It’s especially beneficial for those lacking Vitamin B1, B6, and B12. These vitamins contribute significantly to my health and well-being, especially in regard to managing high cholesterol levels, making them crucial for anyone with deficiencies.
Read More
2
Bright urine noted
Everything is satisfactory, although I did experience a slight side effect. Solgar products are highly regarded for quality, and I believe these vitamins are too. However, I noticed my urine turned bright yellow, which I understand may be linked to vitamin B2. I hope that is the case!
Read More
Frequently Asked Questions
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, results from taking supplements for high cholesterol can vary, but some users report noticeable improvements in relatively short timeframes. For instance, one user indicated a significant decrease in cholesterol levels from 7.9 to 6 after just 1.5 months of taking omega-3, as recommended by their cardiologist Read Review. This suggests that with the right supplementation, individuals may see beneficial results within a couple of months, depending on their specific health conditions and adherence to recommendations.
In general, other users emphasize the importance of supplement quality, particularly from trusted brands like Solgar, which may enhance their effectiveness in managing cholesterol levels Read Review. While specific timelines can differ, it’s advisable to monitor your progress regularly and consult with a healthcare professional to ensure that your chosen supplements align well with your health goals.
When it comes to managing high cholesterol, several dietary supplements show promising results backed by scientific research. A well-designed study on red yeast rice (RYR) demonstrated that a low dose of monacolin K could lead to a significant reduction in low-density lipoprotein (LDL) cholesterol by 14.8% and total cholesterol by 11.2% over 12 weeks [4]. Additionally, a combination of nutraceuticals including red yeast rice, policosanol, and folic acid, was found to be effective, resulting in notable reductions in total and LDL cholesterol levels among participants with high cholesterol [6]. Even more encouraging, research shows that young patients with elevated cholesterol may experience improvements from a mix of plant sterols and omega-3 fatty acids, although results were less impactful [7].
Another intriguing finding involves niacin (vitamin B3), which has shown benefits especially for diabetic individuals, suggesting lower risks of hyperlipidemia [2]. A separate study also highlighted niacin's ability to enhance high-density lipoprotein (HDL) cholesterol while reducing oxidative stress, implying that it not only aids in cholesterol management but may have broader health benefits [8]. Overall, while fuller conclusions require more extensive studies across varied demographics, current research indicates that these supplements can be effective tools in the fight against high cholesterol.
Based on user reviews, individuals taking omega-3 for high cholesterol have reported impressive improvements in their cholesterol levels. One user mentioned a decrease from 7.9 to 6 within just 1.5 months of starting the supplement, highlighting the potential effectiveness of omega-3 as a recommended alternative to statins by healthcare professionals Read Review. This suggests that, for some users, incorporating omega-3 into their routine could yield tangible results relatively quickly, reinforcing the importance of finding the right supplement for individual health needs.
Additionally, users who have taken B-complex vitamins from reputable brands like Solgar have reported various positive effects, such as increased focus, improved hair, skin, and overall health, and enhanced brain function. One review emphasized the significance of B vitamins, specifically for individuals dealing with high cholesterol and other deficits, highlighting its role in hormone production and energy enhancement Read Review. While not all individuals may experience these improvements at the same rate or to the same extent, the anecdotal evidence suggests a strong correlation between high-quality supplementation and better overall health outcomes.
Based on user reviews, there seems to be a positive inclination towards combining omega-3 supplements with B-complex vitamins for managing high cholesterol. Users report significant improvements in their cholesterol levels, with one individual noting a drop from 7.9 to 6 after just 1.5 months of taking omega-3 as recommended by their cardiologist Read Review. This suggests that omega-3 may serve as an effective alternative to traditional statins for some users.
Furthermore, several reviewers have highlighted the benefits of B-complex vitamins, particularly from Solgar, in supporting overall health and managing cholesterol. One user noted that the high-quality formulation of the B-complex significantly improved their focus and overall well-being, contributing to better management of high cholesterol levels Read Review. Another review also supported the idea that these B vitamins are essential for those with specific deficiencies, reinforcing their value when combined with omega-3 in a comprehensive health regimen Read Review. Ultimately, users seem to advocate for the synergistic effects of these supplements in addressing high cholesterol and promoting overall health.
Users report varying opinions on the effectiveness of Vitamin B Complex for treating high cholesterol, yet specific dosage recommendations are not mentioned in the reviews. Some users emphasize the importance of certain vitamins within the B-complex, such as B1, B6, and B12, as being crucial for their overall health and management of cholesterol levels. One user specifically notes that these vitamins contribute significantly to their health, suggesting their importance in a regimen aimed at high cholesterol management Read Review.
While users praise the quality and concentration of ingredients in the B-complex, there is no consensus on a specific dosage that is effective for cholesterol treatment. Instead, users express satisfaction with the overall benefits they've experienced—such as improved focus and energy levels—and generally recommend integrating the B-complex into a health routine for wellness, including for those aiming to address high cholesterol Read Review. Given the lack of explicit dosage recommendations in user experiences, individuals considering Vitamin B Complex for high cholesterol should consult healthcare professionals for personalized advice.
10
Significant cholesterol reduction
3 people found this helpful
I’m amazed at the results from taking omega-3 for my high cholesterol. My cholesterol levels decreased from 7.9 to 6 after just 1.5 months, as advised by my cardiologist, who suggested omega instead of statins. I’m really pleased with the outcome and will continue using it. It's recommended for everyone over 32, and it has certainly worked wonders for me.
7.5
B vitamin potency
1 people found this helpful
I highly recommend Solgar's entire line due to its excellent quality, particularly the high mcg amounts in the B-complex. It’s especially beneficial for those lacking Vitamin B1, B6, and B12. These vitamins contribute significantly to my health and well-being, especially in regard to managing high cholesterol levels, making them crucial for anyone with deficiencies.
7.5
Enhanced focus achieved
55 people found this helpful
The quality and concentration of Solgar's ingredients are exceptional. The B-complex has dramatically increased my focus and improved the health of my hair, skin, and nervous system. Vitamins B1, B2, B3, B6, B9, and B12 help in various ways, including hormone production and enhancing energy. Overall, I believe this B-complex contributes significantly to improved brain function and nervous system health, making it a valuable addition to my routine to address high cholesterol and overall well-being.
9
Monacolin K significantly lowers LDL-C
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention.
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
9
Effective cholesterol reduction noted
Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk.
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
8
Plant sterols and B vitamins show promise
Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study.
We explored the impact of a mix of plant sterols, fish oil, and B vitamins on cholesterol levels in young people with high cholesterol. Over 16 weeks, 25 participants took these supplements daily.
While we saw reductions in harmful cholesterol types, other key markers like triglycerides and inflammation showed minimal improvement. The n-3 fatty acids increased significantly, indicating a potential positive effect on heart health, but overall, results suggest no major breakthroughs in cholesterol management for this demographic.
9
Niacin lowers cholesterol in diabetics
Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults.
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
9
Niacin reduces cholesterol and oxidative stress
Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol.
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
References
Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
Geng X, Lin Z, Zheng Z, Lin Q, Sun T, et al. Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults. Nutr Res. 2024;131:54. doi:10.1016/j.nutres.2024.09.006
Shoman ME, Aboelez MO, Shaykhon MSA, Ahmed SA, Abuo-Rahma GEA, et al. New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity. Mol Divers. 2021;25:673. doi:10.1007/s11030-020-10039-9
Heinz T, Schuchardt JP, Möller K, Hadji P, Hahn A. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016;36:1162. doi:10.1016/j.nutres.2016.07.005
Qin X, Li J, Spence JD, Zhang Y, Li Y, et al. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients. Stroke. 2016;47:2805.
Mazza A, Lenti S, Schiavon L, Zuin M, D'Avino M, et al. Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk. Adv Ther. 2015;32:680. doi:10.1007/s12325-015-0229-x
Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28
Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension. 2012;59:825. doi:10.1161/HYPERTENSIONAHA.111.183210
Marazzi G, Cacciotti L, Pelliccia F, Iaia L, Volterrani M, et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv Ther. 2011;28:1105. doi:10.1007/s12325-011-0082-5